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KMID : 1200820050050040251
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Oriental Pharmacy and Experimental Medicine
2005 Volume.5 No. 4 p.251 ~ p.261
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Can herbal drug(s) meet the challenges of genomewide screen results on rheumatoid arthritis
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Paul Bholanath
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Abstract
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Rheumatoid arthritis (RA) is an autoimmune/inflammatory disorder with a complex genetic component. RA is characterized by chronic inflammation of the synovial membrane in the joint, which leads to the progressive destruction of articular cartilage, ligament and bone. Several cytokines such as tumor necrosis and interleukin-6 (IL-6) have been implicated in the pathological mechanisms of synovial tissue proliferation, joint destruction and programmed cell death in rheumatoid joint. Genome wide screening of subjects suffering from autoimmune diseases especially arthritis revealed linkage to inflammatory molecules like and IL-6, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), nuclear factor-kappaB and human leucocyte antigen/major histocompatibility complex (HLA/MHC) locus. The status of the pharmacological mechanism of herbal drugs in the light of genome wide screening results has been discussed to reinforce the therapeutic potential and the pharmacological basis of the herbal drugs.
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KEYWORD
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Rheumatoid arthritis, Herbal drugs, Genome wide screening, Autoimmune disease
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