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KMID : 1200820050050040331
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Oriental Pharmacy and Experimental Medicine
2005 Volume.5 No. 4 p.331 ~ p.335
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Neuropharmacological screening of the methanolic extract of Hibiscus vitifolius flowers
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Seethalakshmi S
Chamundeeswari D.
Rani S Jamuna
Parvathavardhini S
Vasantha J
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Abstract
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The methanolic extract of Hibiscus vitifolius flowers (HVE), was evaluated for neurophamacological activities by carrying out rota rod, locomotor activity and traction performance in mice and swim endurance activity in rats in different dosages (10, 30 and 100mg/kg body weight). HVE showed a significant effect on central nervous system by increasing the time taken for rota rod, traction performance and locomotor activity while swimming time was found to be decreased when compared to normal control animals. These results suggest that HVE possess significant anxiolytic and anti depressant activity which may be attributed to the presence of flavonoid in HVE.
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KEYWORD
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Hibiscus vitifolius flowers, Rota rod, Traction performance, Locomotor activity, Swimming time
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