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KMID : 1200820060060030161
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Oriental Pharmacy and Experimental Medicine
2006 Volume.6 No. 3 p.161 ~ p.166
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Chrysanthemum morifolium inhibits inflammatory responses in and LPS-induced mouse peritoneal macrophages
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Na Ho-jeong
Cha Dong-Seok
Jeon So-ra
Bu Young-Min
Jeong Won-Hwan
Jeon Hoon
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Abstract
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Chrysanthemum morifolium (CM) is a herb widely used in medicine for the treatment of a variety of diseases. In this study, using mouse peritoneal macrophages, we have examined whether CM affects nitric oxide (NO), tumor necrosis factor and interleukin (IL)-6 induced interferon and lipopolysaccharide (LPS). CM inhibits and LPS-induced NO in dose dependent manner. We also found that CM inhibits pro-inflammatory cytokine, and IL-6. The expression of cyclooxygenase-2 was reduced by CM. These finding means that CM can be used in controlling macrophages-mediated inflammatory disease.
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KEYWORD
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Chrysanthemum morifolium, Nitric oxide, IL-6, COX-2
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