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KMID : 1200820060060030196
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Oriental Pharmacy and Experimental Medicine
2006 Volume.6 No. 3 p.196 ~ p.201
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Hepatoprotective effect of kasni against aflatoxin induced hepatic damage in mice
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Naaz Farah
Abdin MZ
Javed Saleem
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Abstract
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The efficacy of alcoholic extract of Kasni (Cichorium intybus L.) to control hepatic damage induced by aflatoxin was explored in Swiss albino mice. Aflatoxin was administered orally to the mice with a daily dose of body weight till three months. A signifi-cant increased in thio barbituric acid reactive substances (TBARS) levels with concomitant reduction in enzymatic (glutathione-s-transferase, glutathione peroxidase, superoxide dismutase, and catalase) and nonenzymatic (reduced glutathione) antioxidants were shown in aflatoxin treated group of mice. However, there was a significant reduction in increased TBARS levels and elevation in enzymatic. and non enzymatic antioxidant levels in group of mice which received alcoholic extract of kasni (300 mg/kg bw / day) along with aflatoxin. Histopathological analysis of liver samples also confirmed the hepatoprotective effect of kasni extract. These results suggest that kasni shows hepatoprotective effect against aflatoxin induced hepatic damage in mice.
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KEYWORD
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Aflatoxin , Antioxidants, Cichorium intybus L.
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