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KMID : 1200820060060030202
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Oriental Pharmacy and Experimental Medicine
2006 Volume.6 No. 3 p.202 ~ p.207
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Pharmacological studies on roots of Achyranthes aspera Linn
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Shahid IZ
Moniruzzaman M
Das AK
Choudhuri MSK
Ahmed Firoj
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Abstract
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The crude methanol extract of the roots of Achyranthes aspera Linn. was investigated for its possible antinociceptive, diuretic and neuropharmacological activities in animal models. At the dose of 250 and 500 mg/kg body weight, the extract showed a significant antinociceptive effect in acetic acid induced-writhing in mice comparable to that produced by diclofenac sodium, used as standard drug. The crude extract produced significant diuretic effect at the dose of 500 mg/kg of body weight comparable to that produced by furosemide, used as standard drug. The extract also potentiated significantly the pentobarbital induced sleeping time in mice; decreased the open field score in open field test, decreased the number of hole crossed from one chamber in the hole cross test and decreased the head dip responses. The obtained results provide a support for the use of this plant in traditional medicine and its further investigation.
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KEYWORD
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Achyranthes aspera, Antinociceptive activity, Diuretic activity, Neuropharmacological activity
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