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KMID : 1200820060060030208
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Oriental Pharmacy and Experimental Medicine
2006 Volume.6 No. 3 p.208 ~ p.214
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Preliminary pharmacological evaluation of an Ayurvedic formulation Dasamularista
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Rajia Sultana
Choudhuri M Shahabuddin Kabir
Sattar Mafruhi
Shahriar Masum
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Abstract
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In this study the Ayurvedic formulation Dasamularista was studied for its preliminary pharmacological properties using laboratory mice. Dasamularista showed a decrease in food intake and stool formation, while the water content of stool and water intake was higher and the volume of the urine was less. Dasamularista in a slight extent reduced the intestinal motility. This constipating effect was further supported by the significant anti-diarrhoeal property of the formulation in castor oil induced dairrhoea. The tested formulation markedly increased the latent period of diarrhoea and reduced the purging index value. Dasamularista did not alter the acetic acid induced abdominal writhing. Significant reduction on the onset of sleeping time and increased duration of sleep was observed in pentobarbital induced sleeping time test.
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KEYWORD
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Dasamularista, Ayurvedic, Acute metabolic, Gastrointestinal motility, Antidiarrhoeal, Acetic acid writhing, Pentobarbital sleeping
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