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KMID : 1200820060060030237
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Oriental Pharmacy and Experimental Medicine
2006 Volume.6 No. 3 p.237 ~ p.244
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Anti-inflammatory effect of Samultang in human mast cell line HMC-1
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Choi In-Young
Kim Su-Jin
Kang Tae-Hee
Lee Byung-Hee
Lee Joon-Ho
Lee Ju-Young
Kim Hyung-Min
Hong Seung-Heon
Um Jae-Young
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Abstract
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Samultang has been believed for prevention and remedy various blood diseases such as menstrual irregularity, anemia, and metrorrhagia. However, the mechanism that accounts for anti-inflammatory effects of the Samultang is still not fully understood. This study was designed to evaluate whether and how the Samultang could modulate the production of pro-inflammatory cytokines in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 treated-human mast cell line, HMC-1. Samultang inhibited the production of tumor necrosis factor , interleukin (IL)-6, granulocyte macrophage colony stimulating factor (GM-CSF), and vascular endothelial growth factor (VEGF) in HMC-1. Maximal inhibition rate of , IL-6, GM-CSF, and VEGF by 0.1 mg/ml Samultang was about , and , respectively. Samultang partially blocked PMA plus A23187-induced cyclooxygenase (COX)-2 expression. In addition, Samultang inhibited activation of nuclear factor (NF)-kB, and extracellular signal-regulated kinase (ERK) activation. These results suggest that anti-inflammatory effect of Samulatng may be mediated by the suppression of cytokine production and COX-2 activation via down-regulation of NF-kB and ERK activation.
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KEYWORD
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Samultang, Cytokine, COX-2, NF-kB, ERK
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