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KMID : 1200820060060040324
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Oriental Pharmacy and Experimental Medicine
2006 Volume.6 No. 4 p.324 ~ p.329
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Anti-allodynic effect of bee venom on neuropathic pain in the rat
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Lee Bae-Hwan
Chae Youn-Byoung
Hwang Hye-Jeong
Choi Young-Kook
Hahm Dae-Hyun
Han Seung-Moo
Kang Sung-Keel
Lee Hye-Jung
Pyun Kwang-Ho
Shim In-Sop
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Abstract
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Neuropathic pain syndromes resulted from peripheral nerve injury appear to be resistant to conventional analgesics like opioids. However, it has been demonstrated that acupuncture including aqua-acupuncture may be effective in managing neuropathic pain. The present study was conducted to determine if bee venom injection into acupoint ihibits neuropathic pain, which is difficult to be treated by usual analgesics. Under pentobarbital anesthesia, male Sprague-Dawley rats were subjected to neuropathic surgery. Two weeks after nerve injury, mechanical and cold allodynia were tested in order to evaluate the antiallodynic effects of bee venom injection into an acupoint. Intraperitoneal injection of morphine inhibited mechanical allodynia dose-dependently. Bee venom injected into Zusanli acupoint significantly inhibited mechanical and cold allodynia. These results suggest that bee venom-acupuncture as well as morphine is very effective to inhibit mechanical allodynia.
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KEYWORD
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Neuropathic pain, Bee venom, Zusanli, Acupuncture, Morphine
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