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KMID : 1200820070070010046
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Oriental Pharmacy and Experimental Medicine
2007 Volume.7 No. 1 p.46 ~ p.50
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Anticonvulsant potential of callus cultures of Convolvulus microphyllus Sieb.
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Ahmad Sayeed
Zafar Rasheed-Uz
Shahid Mohd
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Abstract
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Callus cultures of Convolvulus microphyllus Sieb. was induced on Murashige and Skoog’s medium supplemented with 2,4-dichloro phenoxy acetic acid, 6-benzyl adenine, indole acetic acid and kinetin (1 ppm each). Methanolic extracts of whole plant, leaf, stem and leaf and stem calli were tested for anticonvulsant activity against standard drug phenytoin using maximal electroshock model on mice. It was observed that the animals treated with methanolic extracts of stem callus, leaf callus and whole plant (200 mg/kg, oral) showed significant protection against tonic convulsions induced by transcorneal electroshock. Anticonvulsant activity of methanolic extract of stem callus was comparable to that of standard drug phenytoin.
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KEYWORD
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Anticonvulsant activity, MES, Convolvulus microphyllus, Callus culture
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