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KMID : 1200820070070030235
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Oriental Pharmacy and Experimental Medicine
2007 Volume.7 No. 3 p.235 ~ p.243
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The anti-allergy and anti-inflammatory effect of Anemarrhenae Rhizoma in vivo and in vitro
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Kim Su-Jin
Jeong Hyun-Ja
Myung Noh-Yil
Moon Phil-Dong
Lee Ju-Young
Yi Byoung-Jae
Lee Eun-Hyub
An Nyeon-Hyung
Park Seok-Jae
Kim Min-Cheol
Jun Suk-Min
Lee Ji-Hyun
Kim Hyung-Min
Hong Seung-Heon
Um Jae-Young
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Abstract
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Anemarrhenae Rhizoma (AR) is used in traditional oriental medicine for various medicinal purposes. However, the exact mechanism that accounts for the anti-allergy and anti-inflammatory effects of the AR is still not fully understood. The aim of The present study is to elucidate whether and how AR modulates the allergic reactions in vivo, and inflammatory reaction in vitro. In this study, we showed that AR significantly decreased compound 48/80-induced systemic anaphylaxis, paw oedema, and histamine release from preparation of rat peritoneal mast cells. Also, AR inhibited the expression of inflammatory cytokine in PMA plus A23187-stimulated human mast cells (HMC-1). In addition, we showed that anti-inflammatory mechanism of AR is through suppression of nuclear factor- activation degradation. These results provided new insight into the pharmacological actions of AR as a potential molecule for therapy of inflammatory allergic diseases.
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KEYWORD
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Anemarrhenae Rhizoma, Allergic reactions, Inflammation, Cytokine, Nuclear factor-
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