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KMID : 1200820070070030280
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Oriental Pharmacy and Experimental Medicine
2007 Volume.7 No. 3 p.280 ~ p.285
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Antinociceptive and antidiarrhoeal activities of Bruguiera gymnorrhiza
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Ahmed F
Shahid IZ
Gain NC
Reza MSH
Sadhu SK
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Abstract
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The methanol extract of leaves of Bruguiera gymnorrhiza (L.) Lam. (Rhizophoraceae) was screened for its antinociceptive and antidiarrhoeal activities. The extract produced significant inhibition in acetic acid-induced writhing in mice at dose of 250 and 500 mg/kg body weight (P < 0.001), comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight (P < 0.001). When tested for its antidiarrhoeal effects on castor oil-induced diarrhea in mice, it increased mean latent period (P < 0.02) and decreased the frequency of defecation (P < 0.01) significantly at the dose of 500 mg/kg body weight, comparable to the standard drug loperamide at the dose of 50 mg/kg of body weight. The overall results tend to suggest the antinociceptive and antidiarrhoeal activities of the extract.
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KEYWORD
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Antinociceptive, Antidiarrhoeal, Bruguiera gymnorrhiza, Rhizophoraceae
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