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KMID : 1200820070070040348
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Oriental Pharmacy and Experimental Medicine
2007 Volume.7 No. 4 p.348 ~ p.356
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Anti-arthritic effect of radix Paeoniae rubra herb-acupuncture: a behavioral evaluation on adjuvant-induced arthritis rats
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Kim Seung-Tae
Hahm Dae-Hyun
Kim Gun-Ho
Park Jong-Bae
Han Dong-Oh
Park Hi-Joon
Shim In-Sop
Park Hee-Myung
Kim Ki-Hyun
Kim Jang-Hyun
Choi Seong-Hun
Lee Hye-Jung
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Abstract
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Radix Paeoniae rubra (PR) has been widely used for recovering acute inflammation with swelling and pain in Far East Asian countries. In order to investigate the anti-arthritic effect of PR herbacupuncture, several behavioral parameters such as body weight, knee circumference, squeaking threshold, and weight distribution ratio were investigated in an adjuvant-induced mono-arthritis rat model. We performed PR herb-acupuncture on Zusanli (ST36) of the right hind-leg once every second day for a total of 6 times from the second day of initiating arthritis with adjuvant injection, while the control group was treated with saline in the same way. In the experimental group, body weight significantly increased, knee circumference and squeaking threshold significantly decreased indicating the reduction of edema, and both the pain and inflammatory swelling of the hind paws measured by incapacitance meter decreased. Conclusively, PR herb-acupuncture has more promising effect in alleviating arthritic pain and inflammation than saline-acupuncture in rat model, hence further clinical study is required.
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KEYWORD
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Radix Paeoniae rubra, Herb-acupuncture, Acupoint, Monoarthritis, Rat
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