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KMID : 1200820070070040390
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Oriental Pharmacy and Experimental Medicine
2007 Volume.7 No. 4 p.390 ~ p.394
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Antinociceptive profile of the ethanolic extract of andrographis paniculata in mice
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Sulaiman MR
Sainan S
Zakaria ZA
Somchit MN
Israf DA
Moin S
Mohamad TA Tengky
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Abstract
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The present study was conducted to evaluate the analgesic activity of ethanolic extract of Andrographis paniculata (AP) in mice. The analgesic investigations were carried out using the acetic acid-induced abdominal writhing and the hot-plate tests. It was demonstrated that intraperitoneal (i.p.) administration of the extract at a dose of 30, 100, 300, 500 mg/kg, produced significant inhibition of abdominal constriction induced with 0.6% (v/v) acetic acid in dosedependent manner. It also demonstrated that the extract produced significant dose-dependent increase in the time of latency to a discomfort reaction in the hot-plate model. In addition, the analgesic effect of the ethanolic extract of AP was significantly reversed by a non-specific opioid receptor antagonist, naloxone. These results indicate that AP has an analgesic effect that was mediated through opioid receptors.
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KEYWORD
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Andrographis paniculata, Ethanolic extract, Antinociceptive activity, Opioid receptor
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