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KMID : 1200820080070050501
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Oriental Pharmacy and Experimental Medicine
2008 Volume.7 No. 5 p.501 ~ p.508
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Analgesic effect of Clematidis Radix (CR) herb-acupuncture in a rat model of pain and inflammation
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Hwang Hye-Jeong
Kim Seung-Tae
Lee Hye-Jung
Kim Young-Suk
Shim In-Sop
Park Hi-Joon
Choi Won-Joo
Kim Jang-Hyun
Hahm Dae-Hyun
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Abstract
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Anti-nociceptive and anti-inflammatory effects of Clematidis Radix (CR)-distillates were investigated in three different pain animal models. Highly purified distillate of CR was injected to Zusanli (ST36) acupoint, called CR herb-acupuncture in the Korean traditional medicine. In tail flick latency test, the CR herb-acupuncture treatment did not show a significant effect of relieving acute phasic pain. To investigate the anti-inflammatory effect of CR herb-acupuncture, inflammatory pain was induced by subcutaneous injection of formalin to the plantar tissue or intra-articular injection of carrageenan to the tibio-tarsal joint in the rats. And the medicinal effect of CR herb-acupuncture was evaluated by analyzing pain behavior such as licking or biting behavior, or by measuring weight distribution ratio between two foot and ankle circumference. In the rat formalin test, the analgesic effect of CR herb-acupuncture was more pronounced in the late phase (for 20 min after the early phase) than in the early phase (for the first 10 min post formalin injection). It also significantly alleviated the carrageenan-induced monoarthritis, in terms of weight distribution ratio and ankle edema. These results revealed that CR herb-acupuncture was effective to treat the inflammatory pain and could be used as an analgesic treatment with an antiinflammatory effect.
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KEYWORD
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Pain, Inflammation, Clematidis Radix, Herb-acupuncture, Rat
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