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KMID : 1200820080070050556
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Oriental Pharmacy and Experimental Medicine
2008 Volume.7 No. 5 p.556 ~ p.563
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Effects of amygdalin on the functional recovery and c-Fos expression in the ventrolateral periaqueductal gray region after sciatic crushed nerve injury in rats
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Kim Toung-Wook
Lim Hyung-Ho
Song Yun-Kyung
Kim Sung-Eun
Lee Jin-Woo
Lee Myoung-Hwa
Seo Jin-Hee
Shin Mal-Soon
Lim Baek-Vin
Kim Chang-Ju
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Abstract
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Peripheral nerve injuries are a commonly encountered clinical problem and often result in a chronic pain and severe functional deficits. The expression of c-Fos is sometimes used as a marker of increased neuronal activity. We have prepared the aqueous extract of amygdalin from Armeniacae semen for pain control. In the present study, we investigated the effects of amygdalin on the recovery rate of the locomotor function and on the expression of c-Fos in the ventrolateral periaqueductal gray (vlPAG) region following sciatic crushed nerve injury in rats. Walking track analysis for the evaluation of functional recovery and immunohistochemistry for the c-Fos expression were used in this study. In the present results, characteristic gait change with dropping of the sciatic function index (SFI) was observed and c-Fos expression in the vlPAG was suppressed following sciatic crushed nerve injury in rats. Amygdalin enhanced SFI value and restored c-Fos expression in the vlPAG to the control value. The present our study indicated that amygdalin activates neurons in the vlPAG, and it facilitates functional recovery following peripheral nerve injury.
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KEYWORD
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Amygdalin, Sciatic crushed nerve injury, Sciatic function index, c-Fos expression, Ventrolateral periaqueductal gray
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