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KMID : 1200820080080010059
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Oriental Pharmacy and Experimental Medicine
2008 Volume.8 No. 1 p.59 ~ p.66
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Effect of Aerva lanata against oxalate mediated free radical toxicity in urolithiasis
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Begum Vava Mohaideen Hazeena
Mahesh Ramalingam
Ramesh Thiyagarajan
Soundararajan Periasamy
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Abstract
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This study was undertaken to evaluate the antioxidant potential of A. lanata on oxalate mediated free radical toxicity in ethylene glycol induced calcium oxalate urolithic rats. Calcium oxalate (CaOX) stone was induced by 0.75% ethylene glycol in drinking water for 28 days. From day onwards, the CaOX urolithic rats were treated with A. lanata aqueous suspension (2,000 mg/kg body weight/dose/day) orally for another 28 days. At the end of experimental periods the animals were sacrificed, samples were collected and analyzed the lipid peroxidation product, protein oxidation product, enzymatic and non-enzymatic antioxidants in normal and experimental groups. Lipid peroxidation and protein oxidation products were significantly elevated while enzymatic and non-enzymatic antioxidant levels were significantly decreased in ethylene glycol induced CaOX urolithic rats when compared with control rats. The above alterations were reverted to near control in rats treated with aqueous suspension of A. lanata. This study suggests that A. lanata could prevent the free radical formation from calcium oxalate urolithiasis in rats and protecting the renal cells from oxidative injury.
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KEYWORD
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Ethylene glycol, Urolithiasis, Free radical, Lipid peroxidation, Anti oxidant
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