|
KMID : 1200820080080020125
|
|
Oriental Pharmacy and Experimental Medicine
2008 Volume.8 No. 2 p.125 ~ p.129
|
|
|
Screening of KMU-4, 6, 7 on inflammatory responses in IFN-γ and LPS-induced mouse peritoneal macrophages
|
|
Na Ho-Jeong
Jeong Hyun-Ja
Ahn Jong-Woong
Um Jae-Young
Kim Hyung-Min
Hong Seung-Heon
|
|
|
Abstract
|
|
|
|
Korean Marine Plants (KMU-4, 6, 7) obtained from an herb which widely used in medicine for the treatment of a variety of pathologies. In this study, using mouse peritoneal macrophages, we have examined whether KMU-4, 6, 7 affects nitric oxide (NO) and COX-2 induced IFN- and LPS and cell viability. KMU-6 inhibits IFN- and LPS-induced NO. We found that KMU-6 had a little effect on COX-2 expression. These finding means that KMU-6 can be used in controlling macrophages mediated inflammatory disease. The present results indicate that KMU-6 has an inhibitory effect on the production of NO through down-regulation of COX-2 expression in LPS stimulated mouse peritoneal macrophages.
|
|
|
KEYWORD
|
|
|
Nitric oxide, COX-2
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|