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KMID : 1200820080080020204
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Oriental Pharmacy and Experimental Medicine
2008 Volume.8 No. 2 p.204 ~ p.206
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Cytotoxicity and antinociceptive activity of Jasminum sambac leaves
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Islam Md Rahatul
Rouf Razina
Barua Juwel
Uddin Shaikh Jamal
Alamgir Mahiuddin
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Abstract
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The ethanolic extract of Jasminum sambac leaves were tested for its cytotoxicity and possible antinociceptive activity in experimental animals. The extract showed potent cytotoxic activity in brine shrimp lethality assay and the LC50 was found only 25 mg/ml. The extract significantly and dose dependently inhibited the acetic acid induced writhing in mice (56.83%, P < 0.001 and 43.17%, P < 0.001 for 500 and 250 mg/kg body weight, respectively). The results supported its traditional uses.
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KEYWORD
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Jasminum sambac, Cytotoxicity, Antinociceptive, Brine shrimp
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