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KMID : 1200820080080030222
Oriental Pharmacy and Experimental Medicine
2008 Volume.8 No. 3 p.222 ~ p.227
Effect of Citrus aurantium var amara on weight change in mice
Sarker Satyajit Dey

Habibi Bohlol
Sharifi Tohid
Asnaashari Solmaz
Nahar Lutfun
Delazar AndAbbas
Abstract
Citrus aurantium var. amara L., commonly known as ¡¯bitter orange¡¯ or ¡¯sour orange¡¯, of the family Rutaceae, has traditionally been used in the treatment of various ailments, and it possesses different types of pharmacological properties. As a part of our on-going studies on the plantsfrom the Iranian flora, the extract of C. aurantium var. amara has been studied for its weight lossproperties using the mice model. While the Sep-Pak fraction, 20% methanol (MeOH) in water, of the hydro-methanolic extract of the peels of C. aurantium var. amara fruits, when injectedintraperitoneal (i.p.) at a dose of 10 mg/kg, significantly decreased the level of weight gain of the mice in comparison with control the group (P < 0.01), the Sep-Pak fraction 80% MeOH in water decreased the initial weight of mice by 0.44% in six weeks. The administration of the total extract(10 and 20 mg/kg, i.p.), and the Sep-Pak fractions, 40% and 60% MeOH in water (10 mg/kg, i.p.)did not show any significant change of weight of the test mice. Of the two active fractions, the80% MeOH in water fraction did not show any noticeable adverse effects on mice, and was therefore analysed by reversed-phase preparative high performance liquid chromatography resulting in the isolation and identification of four major components, two coumarins, meranzin hydrate (1) and bergamottin (2), and two flavonoids, xanthomicrol 5,4¡¯-di-methyl ether (tangeritin, 3) and hymenoxin 5,7-di-methyl ether (nobiletin, 4).
KEYWORD
Rutaceae, Citrus aurantium var. amara, Coumarin, Flavonoid, Weight reduction
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