|
KMID : 1200820080080030286
|
|
Oriental Pharmacy and Experimental Medicine
2008 Volume.8 No. 3 p.286 ~ p.294
|
|
|
Investigation into the mechanism of anti-asthmatic action of Lepidium sativum
|
|
Goyal BR
Goyal RK
Mehta Anita A
|
|
|
Abstract
|
|
|
|
We have studied the possible mechanism of anti-asthmatic action of ethanolic extracts of dried seeds of Lepidium sativum (EXLS, 400 mg/kg) using various experimental models. EXLS produced an increase in the Pre-Convulsion Dyspnoea time induced by histamine and acetylcholine aerosol, a significant reduction in the elevated leucocyte counts in the Broncho-Alveolar Lavage fluid of sensitized guinea-pigs and reduction in the paw edema volume as compared to the control rats. Treatment with EXLS also produced decrease in the elevated histamine release from the sensitized guinea-pig lungs. The anti-asthmatic anti-inflammatory responses of EXLS was supported by improvement in microscopic changes like infiltration of inflammatory cells, submucosal edema, epithelial desquamation and reduced lumen size of the bronchi. The values of histamine in tracheal chain and taenia-coli were significantly greater and that in lung strip was lower in the sensitized animals as compared to control. Treatment of sensitized guinea pigs with EXLS significantly decreased values of histamine in all three preparations. Our data suggest the prevention of hyper-responsiveness in bronchial smooth muscles and inhibition of the immediate hypersensitive reaction, histamine release in the lungs and the infiltration of various inflammatory cells as the possible mechanisms of anti-asthmatic activity of EXLS.
|
|
|
KEYWORD
|
|
|
Lepidium sativum, Asthma, Histamine
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|