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KMID : 1200820080080040323
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Oriental Pharmacy and Experimental Medicine
2008 Volume.8 No. 4 p.323 ~ p.328
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Antibacterial, cytotoxic and neuropharmacological activities of Cerbera odollam seeds
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Ahmed F
Amin R
Shahid IZ
Sobhani MME
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Abstract
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The MeOH extract of seeds of Cerbera odollam Gaertn. (Apocynaceae) was screened for its antibacterial, cytotoxic and neuropharmacological activities. The extract showed moderate anti-bacterial activity against Salmonella typhi, Streptococcus saprophyticus, and Streptococcus pyogenes. It exhibited high level cytotoxicity against brine shrimp (: ). The extract potentiated pentobarbital induced sleeping time in mice which was further supported by the exploratory behavior test at dose of 25 mg/kg. The overall results tend to suggest the antibacterial, cytotoxic and CNS depressant activities of the extract.
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KEYWORD
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Cerbera odollam, Antibacterial activity, Cytotoxic activity, CNS depressant activity
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