|
KMID : 1200820080080040339
|
|
Oriental Pharmacy and Experimental Medicine
2008 Volume.8 No. 4 p.339 ~ p.348
|
|
|
Anti-Salmonella activity of a flavonone from Butea frondosa bark in mice
|
|
Mishra Uma Shankar
Dutta Noton Kumar
Mazumdar Kaushiki
Mahapatra Santosh Kumar
Chakraborty Pronobesh
Dastidar Sujata G
|
|
|
Abstract
|
|
|
|
Butea frondosa has been used traditionally as a topical formulation in the treatment of many diseases and disorders. Two compounds [BF-1 (crystalline flavonol quercetin) and BF-2 (tannin) from ethyl acetate fraction of ethanolic extract] were isolated from the bark of Butea frondosa. The stereostructures of the compounds were determined on the basis of chemical and physicochemical evidence. BF-1 and BF-2 were screened in vitro for possible antibacterial property against 112 bacteria comprising 3 genera of Gram-positive and 12 genera of Gram-negative types. It was found that both BF-1 and BF-2 exhibited inhibitory activity against several bacteria. Most of these strains were inhibited by BF-1 at , while BF-2 ( ) was much less active. The bacteria could be arranged in the decreasing order of sensitivity towards BF-1 in the following manner: S. aureus, Bacillus spp., Salmonella spp., Vibrio spp., Shigella spp., E. coli and Pseudomonas spp. The of the compound was while the was . The decreasing order of sensitivity towards BF-2 was V. cholerae, Bacillus spp., S. aureus, V. parahaemolyticus, Salmonella spp. and Proteus spp. BF-1 was bactericidal in action. In vivo studies with this extract showed that it could offer statistically significant protection (p < 0.01) to mice challenged with a virulent bacterium. The inhibitory activity of Butea frondosa against Gram-positive and Gram-negative bacteria indicates its usefulness in the treatment of common bacterial infections. The potentiality of BF-1 as an antibacterial agent may be confirmed further by pharmacological studies.
|
|
|
KEYWORD
|
|
|
Butea frondosa, ethyl acetate fraction, quercetin, antimicrobial activity, in vitro, in vivo
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|