|
KMID : 1200820080080040365
|
|
Oriental Pharmacy and Experimental Medicine
2008 Volume.8 No. 4 p.365 ~ p.373
|
|
|
Nootropic Potential of Murraya koenigii leaves in Rats
|
|
Vasudevan Mani
Parle Milind
Sengottuvelu Singaravel
Shanmugapriya Thulasimani
|
|
|
Abstract
|
|
|
|
Murraya koenigii leaves commonly known as ’curry patta’ are routinely added to Indian gravy and vegetarian dishes by south Indian as a favourate condiment. The present study was undertaken to investigate the effects of Murraya koenigii leaves (MKL) on memory in rats. Elevated plus-maze and Hebb-Williams maze served as the exteroceptive behavioral models for testing memory. Diazepam-, scopolamine- and ageing-induced amnesia served as the interoceptive behavioral models. MKL fed orally to various groups of young and aged rats with diet containing 2, 4 and 8% w/w of MKL for 30 days consecutively were investigated. The MKL diets produced a significant dose-dependent improvement in memory scores of young and aged rats and significantly reduced the amnesia induced by scopolamine (0.4 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.). Therefore, it would be worthwhile to specifically investigate the therapeutic potential of MKL in the management of dementia patients.
|
|
|
KEYWORD
|
|
|
Amnesia, Memory, Murraya koenigii
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|