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KMID : 1200820080080040386
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Oriental Pharmacy and Experimental Medicine
2008 Volume.8 No. 4 p.386 ~ p.394
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Pharmacological and Biochemical studies on Telescopium telescopium - a marine mollusk from the Mangrove regions
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Samanta SK
Adhikari D
Karmakar S
Dutta A
Roy A
Manisenthil KT
Roy D
Sen T
Vedasiromoni JR
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Abstract
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The tissue extract (TTE) of a marine snail Telescopium telescopium, collected from the coastal regions of West Bengal, India, was extensively screened for pharmacological and biochemical properties. Telescopium telescopium (TTE) produced significant lysis of washed rat erythrocytes (both direct and indirect), produced haemorrhagic lesions in the skin and also released haemoglobin (in vitro tissue damage) from different tissue samples. TTE was found to produce pro-inflammatory effects when injected into the rat hind paw and also increased peritoneal vascular permeability. Furthermore, intravenous administration of TTE produced a decrease in blood pressure (hypotensive effect) in anaesthetized rats. The extract produced potent esterase activity, as was evident from the breakdown of FDA with subsequent release of fluorescein (in vitro). TTE also demonstrated prominent cholinesterase, phospholipase, phosphatase and protease activities.
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KEYWORD
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Mollusk, Telescopium telescopium, Haemolysis, Oedema, Phospholipase, Cholinesterase
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