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KMID : 1200820080080040408
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Oriental Pharmacy and Experimental Medicine
2008 Volume.8 No. 4 p.408 ~ p.415
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Search towards an insight for comparative anti-tumour effects of Wrightia tomentosa leaf & bark in ehrlich ascites carcinoma bearing mice
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Nagarajan K
Mazumder Avijit
Ghosh LK
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Abstract
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In the present study, the ethanolic leaf and bark extract of Wrightia tomentosa were tested for comparative in vivo antitumour properties against Ehrlich ascites carcinoma (EAC) tumour bearing mice at 100 and 200 mg/kg body weight doses given orally once daily for 16 days. The EAC mice receiving 100 and 200 mg/kg ethanolic leaf and bark extract showed a dose dependent elevation in tumour, free survival and a highest number of survivors were observed at 200 mg/ kg for leaf extract of ethanol, which was considered as an optimum dose for its anti neoplastic action. The Median survival time for this dose was approximately 44 days when compared with 23 days of non-drug treated controls. The results indicate that the administration of leaf extract not only increased the survival of animals with ascites tumour and reduced packed cell volume and viable tissue cell count, but also altered many hematological parameters changed during tumour progression, indicating the potent antitumour nature of leaf extract than the bark extract. Statistical analysis also reveals that the leaf extract showed highly significant anti tumour potency (p < 0.001) when compared with control.
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KEYWORD
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Wrightia tomentosa, Ethanol extract, Leaf, Bark, Ehrlich ascites carcinoma (EAC), antitumour
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