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KMID : 1200820080080040440
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Oriental Pharmacy and Experimental Medicine
2008 Volume.8 No. 4 p.440 ~ p.447
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Panax Ginseng inhibited HIF-1a activation and inflammatory cytokine in HMC-1 cells activated by phorbol myristate acetate and A23187
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Choi In-Young
Jeong Hyun-Ja
An Hyo-Jin
Kang Tae-Hee
Zo Chul-Won
Song Bong-Keun
Park Eun-Jeong
Kim Eun-Cheol
Um Jae-Young
Kim Hyung-Min
Hong Seung-Heon
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Abstract
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This study investigated the role of Panax ginseng (PG) on the phorbol myristate acetate (PMA) + calcium ionophore A23187-induced hypoxia-inducible factor- (HIF-) activation, phosphorylation of the extracellular signal-regulated kinase (ERK), and inflammatory cytokine production from the human mast cell line, HMC-1. HIF- and phosphorylation of ERK were observed by Western blotting. The inflammatory cytokine production was determined by enzyme-linked immunosorbent assay. PG inhibited the PMA+A23187-induced HIF- expression and the subsequent production of vascular endothelial growth factor. In addition, PG suppressed PMA + A23187-induced phosphorylation of ERK. We also show that the increased cytokines interleukin (IL)-, IL-6, and tumour necrosis factor- level was significantly inhibited by treatment of PG. In the present study, we report for the first time that PG is an inhibitor of HIF- and cytokines on the mast cell-mediated inflammatory responses.
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KEYWORD
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panax ginseng, hypoxia-inducible factor-, extracellular signal-regulated kinase, cytokines, mast cells
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