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KMID : 1200820090090010074
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Oriental Pharmacy and Experimental Medicine
2009 Volume.9 No. 1 p.74 ~ p.82
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Anti-inflammatory activity of aqueous methanolic extract of Swietenia mahagoni (L.) Jacq. (Meliaceae) leaves
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Roy S
Besra SE
Banerjee B
Mukherjee J
Vedasiromoni JR
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Abstract
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Pharmacological investigations were carried out with aqueous methanolic extract (AME) of Swietenia mahagoni (L.) Jacq. (Meliaceae) leaves. Acute toxicity studies revealed that the dose of AME was 600 mg/kg, i.p. AME was found to possess significant anti-inflammatory activity in acute, sub-chronic and chronic models of inflammation. AME selectively inhibited cyclooxygenase (COX)-2 activity, which is involved in arachidonic acid metabolism and biosynthesis of prostaglandins under inflammatory conditions. Treatment with AME significantly enhanced total peritoneal cell count and the number of macrophages in normal mice, which revealed that AME may also alter the immune response along with its anti-inflammatory effect. The saponins or the alkaloids present in AME may be responsible for the anti-inflammatory activity.
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KEYWORD
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Swietenia mahagoni leaf, Anti-inflammatory activity, Cyclooxygenase-2 inhibition
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