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KMID : 1200820090090010090
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Oriental Pharmacy and Experimental Medicine
2009 Volume.9 No. 1 p.90 ~ p.96
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Antibacterial effect of naturally occurring unsaturated fatty acids from Prunus japonica against Propionibacterium acnes
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Sultan Md Zakir
Lee Ki-Moo
Moon Surk-Sik
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Abstract
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The antibacterial activity-guided fractionation of the MeOH extract of seeds of traditional medicinal plant Prunus japonica resulted in the isolation of linoleic acid and cis-11-eicosenoic acids, and their methyl esters. Linoleic acid inhibited the growth of Propionibacterium acnes, the acne-causing anaerobic bacterium, but cis-11-eicosenoic acid, methyl linoleate, and cis-11-eicosenoate were found to be inactive. Together with isolated linoleic acid, authentic saturated and unsaturated fatty acids were also tested against P. acnes with other bacteria and fungi. Most of the unsaturated fatty acids possessed anti-acne (MIC ) and antimicrobial properties.
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KEYWORD
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Propionibacterium acnes, Prunus japonica, Rosaceae, fatty acids, antibacterial, antifungal
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