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KMID : 1200820090090020157
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Oriental Pharmacy and Experimental Medicine
2009 Volume.9 No. 2 p.157 ~ p.163
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Anti-inflammatory activity of methanol extract isolated from stem bark of Albizia julibrissin
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Na Ho-Jeong
Cha Dong-Seok
Jeon Hoon
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Abstract
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Albizia julibrissin (AJ) has been used widely as a traditional medicine. In macrophages nitric oxide (NO) is released as an inflammatory mediator and has been proposed to be an important modulator of many pathophysiological conditions including inflammation and carcinogenesis. In this study we have examined the NO inhibition effect of 85% methanol extracts of AJ in mouse macrophage. Lipopolysaccharide (LPS) has been reported to induce production of NO. Extracts of AJ (1, 10, ) suppressed nitric oxide production in LPS-stimulated () mouse (C57BL/6) macrophages and analyzed by ELISA. In addition, it also attenuated the expression of inflammatory products like Interleukin-6 (IL-6), cyclooxygenase-2 (COX-2), and inducible NOS (iNOS) as assessed by immunoblotting with specific antibodies. These results suggest that 85% methanol extracts of AJ would be useful in inflammatory diseases.
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KEYWORD
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Albizia julibrissin, Nitric oxide, IL-6, Cyclooxygenase-2
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