|
KMID : 1200820090090020164
|
|
Oriental Pharmacy and Experimental Medicine
2009 Volume.9 No. 2 p.164 ~ p.173
|
|
|
Suppressive effect of Spirulina fusiformis in relation to lysosomal acid hydrolases, lipid peroxidation, antioxidant status, and inflammatory mediator TNF-alpha on experimental gouty arthritis in mice
|
|
Rasool Mahaboob Khan
Sabina Evan Prince
Nithya Pichandy
Lavanya Kumar
|
|
|
Abstract
|
|
|
|
The anti-inflammatory effect of Spirulina fusiformis on monosodium urate crystal-induced inflammation in mice has been investigated and compared with the non-steroidal anti-inflammatory drug Indomethacin. The paw volume, lysosomal enzyme activities, lipid peroxidation, anti-oxidant status and inflammatory mediator tumour necrosis factor- were studied in control and monosodium urate crystal-induced mice after oral administration of Spirulina platensis in an experimental model for gouty arthritis. In the induced mice, the levels of lysosomal enzymes, inflammatory mediator tumour necrosis factor-, lipid peroxidation and the paw volume increased significantly, whereas the antioxidant status decreased when compared to control mice. -glucuronidase and lactate dehydrogenase level were also found to be increased in untreated monosodium urate crystal-incubated polymorphonuclear leucocytes. After the oral administration of Spirulina fusiformis, the physical and biochemical changes observed in monosodium urate crystal-induced animals were significantly restored to near normal levels. The results clearly indicated the anti-inflammatory role of Spirulina fusiformis, a promising drug for gouty arthritis.
|
|
|
KEYWORD
|
|
|
Spirulina fusiformis, Inflammation, Tumour necrosis factor-, Gouty arthritis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|