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KMID : 1200820090090020189
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Oriental Pharmacy and Experimental Medicine
2009 Volume.9 No. 2 p.189 ~ p.191
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Anti-cancer effect of Eriocaulon sieboldianum through the activation of caspase-3 in human leukemia cell line, HL-60 cells
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Kim Su-Jin
Lee Gi-Tak
Lee Bo-Ra
Jeon Kwon-Su
Rim Hong-Kun
Bang Jun-Ho
Kim Yang-Gwi
Myung No-Yil
Moon Phil-Dong
Kim Na-Hyung
Choi In-Young
Choi Young-Jin
Kang In-Cheol
Um Jae-Young
Hong Seung-Heon
Kim Hyung-Min
Jeong Hyun-Ja
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Abstract
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Eriocaulon sieboldianum (ES) is used in traditional oriental medicine for various medicinal purposes including headache, toothache, and inflammation. However, the anti-cancer effect of the ES is still not fully understood. In the present study, the human leukemia cell line HL-60 was used to characterize the apoptotic effects of ES. ES induced cytotoxicity of HL-60 cells in a dose- and time-dependent manner. ES induced the generation of reactive oxygen species, and the release of cytochrome c in a dose-dependent manner. In addition, we showed that ES-induced apoptosis was accompanied by activation of caspase-3. Taken together, our results demonstrate that ES possesses anti-cancer activity in HL-60 cells.
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KEYWORD
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Eriocaulon sieboldianum, Reactive oxygen species, Cytochrome c, Caspase-3
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