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KMID : 1200820090090030232
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Oriental Pharmacy and Experimental Medicine
2009 Volume.9 No. 3 p.232 ~ p.237
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Analgesic and anti-inflammatory activity of a polyherbal formulation (PHFAROGH)
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Mohan M
Gulecha VS
Aurangabadkar VM
Balaraman R
Austin Anoop
Thirugnanasampathan S
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Abstract
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The effect of arogh, a polyherbal formulation-PHF [each 3 g powder contained Nelumbo nucifera G. (0.24 g), Hemidesmus indicus R. (0.24 g), Zingiber officinale R. (0.24 g), Terminalia chebula R. (0.24 g), Quercus infectoria O. (0.12 g), Hibiscus rosa-sinensis L. (0.24 g), Rosa damascene M.(0.24 g), Eclipta alba H.(0.24 g), Glycyrrhiza glabra L. (0.24 g)] was investigated in various experimental models of pain and inflammation. Analgesic activity of PHF was studied in mice using acetic acid induced writhing, tail immersion and hot plate methods. Anti-inflammatory activity of PHF was studied in rats using carrageenan induced hind paw edema and formalin induced rat paw edema methods. PHF significantly (P < 0.05) reduced the number of writhings, increased latency to flick tail in tail immersion method and elevated the mean basal reaction time in hot plate method. PHF significantly (P < 0.05) inhibited carrageenan induced hind paw edema and formalin induced rat paw edema. The PHF was tested at dose of 30, 100, 300 and 500 mg/kg.
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KEYWORD
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PHF, Analgesic, Anti-inflammatory, Acetic acid, Carrageenan, Formalin
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