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KMID : 1200820090090040285
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Oriental Pharmacy and Experimental Medicine
2009 Volume.9 No. 4 p.285 ~ p.291
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The protective effect of anti-oxidant in cadmium-induced hair cell death
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Kim Su-Jin
Myung No-Yil
Jeong Hyun-Ja
Um Jae-Young
Kim Hyung-Min
Hong Seung-Heon
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Abstract
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Cadmium (Cd2+) is a heavy metal and a potent carcinogen implicated in tumor development through occupational and environmental exposure. However, the auditory effect of Cd2+ is not poorly understood. The purpose of the present study was to investigate whether prevent the ototoxic effects of Cd2+ by antioxidnat in auditory cell line, HEI-OC1. Rosmarinic acid is a naturally occurring phenolic compound and also known to possess marked antioxidant properties. We showed that antioxidnat inhibited the the cytochrome c release induced by Cd2+. In addition, we showed that the regulatory effect of antioxidnat on apoptosis is through the caspase-9 activation, and extracellular signal-regulated kinase activation in auditory cells. These results suggested antioxidnat its therapeutic usefulness, against Cd2+ induced activation of
caspase-9 and ERK.
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KEYWORD
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Cadmium, Antioxidant, Reactive oxygen species, Extracellular signal-regulated kinase
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