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KMID : 1200820090090040292
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Oriental Pharmacy and Experimental Medicine
2009 Volume.9 No. 4 p.292 ~ p.302
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Hesperidin improves warm ischemia/reperfusion-induced oxidative renal injury in rats
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Gandhi IndiaChintan
Zalawadia Rishit
Balaraman R
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Abstract
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Ischemia/reperfusion injury, which is commonly seen in the field of renal surgery or transplantation, is a major cause of acute renal failure. Previous studies showed that antioxidant treatments attenuated renal ischemia/reperfusion injury. The objective of this study was to examine the role of hesperidin in modulating reactive oxygen species induced inflammation and apoptosis after renal ischemia/reperfusion injury. Rats were subjected to right nephrectomy, 15 days later 45 min of renal ischemia and 24 h reperfusion with or without treatment with hesperidin. Renal function, inflammation and apoptosis were compared at 24 h after reperfusion injury. Hesperidin improved the renal dysfunction and reduced inflammation and apoptosis after ischemia/reperfusion injury. In conclusion, hesperidin shows potent anti-apoptotic and antiinflammatory properties due to antioxidant property. These findings may have major implications in the treatment of human ischemic acute renal failure.
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KEYWORD
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Antioxidant, Hesperidin, Ischemia reperfusion injury, Renal ischemia
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