|
KMID : 1200820090090040315
|
|
Oriental Pharmacy and Experimental Medicine
2009 Volume.9 No. 4 p.315 ~ p.319
|
|
|
A pentacyclic triterpenoid possessing analgesic and anti-inflammatory activities from the fruits of Dregea volubilis
|
|
Biswas M
Biswas K
Ghosh AK
Haldar PK
|
|
|
Abstract
|
|
|
In present study evaluate the analgesic and anti-inflammatory activity of the compound obtained from the petroleum ether (40 - 60°C) extract of the fruits from Dregea volubilis in Swiss albino mice and in Wister albino rats respectively. Dried and crushed fruits of Dregea volubilis were extracted by petroleum ether (40 - 60°C), the proper solvent system was developed by TLC and subjected to column chromatography for obtaining the pure compound/s. IR, MASS, NMR (PMR, C13 NMR
and DEPT) spectroscopic analysis were done to elucidate the structure of the compound/s. The petroleum ether (40 - 60°C) extract of the fruits of Dregea volubilis led to isolation of a pentacyclic triterpenoid designated as taraxerone and characterized as D- friedoolean- 14- en, 3 one. Taraxerone had been screened for analgesic activity in Swiss albino mice and anti-inflammatory activity in Wister albino rats at the dose of 5 mg/kg body weight orally and exhibit significant
analgesic and anti-inflammatory properties.
|
|
|
KEYWORD
|
|
|
Dregea volubilis Benth, Pentacyclic triterpenoid, Taraxerone, Spectroscopy (IR, MASS, C13NMR, PMR, DEPT), Analgesic activity, Anti-inflammatory
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|