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KMID : 1200820100100010001
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Oriental Pharmacy and Experimental Medicine
2010 Volume.10 No. 1 p.1 ~ p.6
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A comparative study of radioprotection with Callophyllis japonica extract and amifostine against lethal whole body gamma irradiation in mice
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Shin Tae-Kyun
Kim Hee-Chul
Kim Jeong-Tae
Ahn Mee-Jung
Moon Chang-Jong
Hyun Jin-Won
Jee Young-Heun
Lee Nam-Ho
Park Jae-Woo
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Abstract
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The efficacy of the radioprotective effect of Callophyllis japonica ethyl acetate (CJEA) extract was studied by comparing it to that of amifostine, a well-known radioprotective agent, and by evaluating the dose reduction factor, an indicator of radioprotective efficacy. Pretreatment with CJEA extract (100 mg/kg body weight) prior to receiving 12 Gy irradiation significantly improved the survival of jejunal crypts at 3.5 day post-irradiation, but attenuated the level of malondialdehyde compared to vehicle alone (P < 0.01). A similar gastroprotective effect was also obtained in the amifostine-treated irradiated group (P < 0.01). The efficacy of the radioprotective effect was further confirmed by the dose reduction factor, 1.41. Collectively, these results suggest that CJEA extract is a useful radioprotectant whose efficacy is similar to that of amifostine and whose radioprotective mechanism is in part the reduction of lipid peroxidation caused by gamma irradiation.
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KEYWORD
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Callophyllis japonica, Red seaweed, Jejunum, Radioprotection, Amifostine, Antioxidation
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