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KMID : 1200820100100010037
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Oriental Pharmacy and Experimental Medicine
2010 Volume.10 No. 1 p.37 ~ p.43
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Palmitic acid inhibits inflammatory responses in lipopolysaccharide-stimulated mouse peritoneal macrophages
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Lee Ju-Young
Lee Hye-Ja
Jeong Ji-Ahn
Jung Ji-Wook
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Abstract
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Palmitic acid (PA) is one of free fatty acids, which is found from Gaultheria itoana Hayata and Sarcopyramis nepalensis. Although PA has a variety of pharmacological effects including mediates hypothalamic insulin resistance, induces IP-10 expression, and promote apoptotic activities, the anti-inflammatory mechanism of PA in mouse peritoneal macrophages remains unclear. In this study, we showed that PA exerted an anti-inflammatory action through suppression the production of tumor necrosis factor-α, interleukin-6, cyclooxygenases-2 and nitric oxide in lipopolysaccaride-stimulated mouse peritoneal macrophages. Our study suggests an important molecular mechanism of PA, which might explain its beneficial effect in the regulation of inflammatory reactions.
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KEYWORD
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Palmitic acid, Tumor necrosis factor-, Interleukin-6, Cyclooxygenases-2, Nitric oxide
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