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KMID : 1200820100100010044
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Oriental Pharmacy and Experimental Medicine
2010 Volume.10 No. 1 p.44 ~ p.49
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Inhibitory effect of sakuranetin on (1,3)-β-glucan synthase
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You Myung-Ja
Kim Bo-Mi
Bhatt Lok-Ranjan
Chai Kyu-Yun
Baek Seung-Hwa
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Abstract
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An examination of the kinetic properties of UDP-glucose, (1,3)-β-glucans (callose) synthase, from mung bean seedlings (Sorbus commixta cortex) shows that these enzymes have a complex relationship with UDP-glucose and various effectors. Fluorescence assay showed that deoxynojirimycin increased the inhibitory effect of (1,3)-β-glucan synthase in a concentration-dependent manner. The inhibitory effect of sakuranetin (34.34%) was higher than that of deoxynojirimycin (80.63%). Disk diffusion method revealed that sakuranetin inhibited the growth of Candida albicans to a 1.5 mm inhibition zone. These results suggest that sakuranetin, isolated from Sorbus commixta cortex extract, can be used as stable antifungal material.
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KEYWORD
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(1, 3)-β-glucan synthase, Sorbus commixta cortex, Fluorescence assay, Inhibitory effect, Sakuranetin, Candida albicans
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