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KMID : 1200820100100020051
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Oriental Pharmacy and Experimental Medicine
2010 Volume.10 No. 2 p.51 ~ p.58
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Effects of Vitex rotundifolia on radical scavenging and nitric oxide production
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Choi Jae-Ki
Cha Dong-Seok
Lee Yong-Jae
Ko Sung-Hoon
Park Ho-Jun
Lee Se-Yeoun
Choi Jae-Hyuk
Jeon Hoon
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Abstract
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Vitex rotundifolia (V. rotundifolia) has been used for treating headache, dizziness, toothache and removal of fever as a traditional medicine in Korea. In the present study, we examined the antioxidant and anti-inflammatory activities of 85% methanol extract of V. rotundifolia. In various radical scavenging assays, V. rotundifolia exhibited strong scavenging effect on 1, 1-diphenyl-2-picrylhydrazyl free radical, superoxide radical, nitric oxide. To elucidate the anti-inflammatory properties of V. rotundifolia, we investigated the inhibition effects of nitric oxide production in IFN-gamma and LPS-stimulated mouse peritoneal macrophages. V. rotundifolia suppressed nitric oxide production, iNOS and COX-2 expression dose-dependently through suppression of NF-eB activation without notable cytotoxicity. These findings mean that V. rotundifolia may be beneficial in oxidative stress-mediated inflammatory disorders.
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KEYWORD
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Vitex rotundifolia, Antioxidant, Anti-inflammatory
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