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KMID : 1200820100100020116
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Oriental Pharmacy and Experimental Medicine
2010 Volume.10 No. 2 p.116 ~ p.122
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The improving effects of Saengmaeksan on ulcerative colitis
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Kim Min-Cheol
Kim Su-Jin
Choi In-Young
Kee Ji-Ye
Kim Dae-Seung
Jeon Yong-Deok
Bae Go-Eun
Choi Sun-Kyung
Jeong Hyun-Ja
Park Yun-Jum
Kim Hyung-Min
Um Jae-Young
Hong Seung-Heon
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Abstract
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Saengmaeksan (SMS) is a well known Korean traditional herbal prescription, which consists of 3 different herbs, Radix Ophiopogonis, Radix Ginseng, and Fructus Schisandrae. SMS has been commonly used in various disease including respiratory system and cardiovascular System in Korea. The objective of this study is to find out the improving effects of SMS against Dextran Sulfate Sodium (DSS)-induced ulcerative colitis. SMS reduced clinical signs of DSS-induced colitis, including body weight loss, shorten colon length, and increased disease activity index. The results showed that SMS significantly inhibited the activation of nuclear factor-kB p65 in the colon tissues of DSS-treated mice. In addition, we observed that result showed that the levels of IL-6 in plasma were increased in DSS treated group compared to those of the normal group, but these increased levels were reduced by administration with SMS. Taken together, these findings suggest that SMS has improving effects on DSS-induced ulcerative colitis, which may explain its beneficial effect in the regulation of chronic intestinal inflammation.
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KEYWORD
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Saengmaeksan, Dextran Sulfate Sodium, Ulcerative colitis, Nuclear factor-κB p65, Interleukin-6
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