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KMID : 1200820100100030214
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Oriental Pharmacy and Experimental Medicine
2010 Volume.10 No. 3 p.214 ~ p.221
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Clematis chinensis suppresses lipopolysaccharide-induced expressions of inducible nitric oxide synthase and cyclooxygenase-2 in mouse BV2 microglial cells
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Chun Hae-Jin
Lee Choong-Yeol
Lee Jin-Woo
Sung Yun-Hee
Kim Sung-Eun
Kim Young-Sick
Shin Mal-Soon
Kim Chang-Ju
Lee Hye-Jung
Kim Dong-Hee
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Abstract
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Clematis chinensis is the root of Clematis chinensis OSBECK and is classified in Ranunculaceae. Clematis chinensis is a traditional medicinal herb possesses analgesic, diuretic, anti-tumorigenic, and anti-inflammatory effects. In this study, the effect of aqueous extract of Clematis chinensis against lipopolysaccharide-induced inflammation was investigated in mouse BV2 microglial cells. The aqueous extract of Clematis chinensis at the respective concentration was treated one hour before the lipopolysaccharide treatment in mouse BV2 microglial cells. From the present results, pre-treatment with the aqueous extract of Clematis chinensis suppressed prostaglandin E2 synthesis and nitric oxide production by inhibiting on the lipopolysaccharide-stimulated cyclooxygenase-2 and inducible nitric oxide synthase expressions in mouse BV2 microglial cells. The present study suggests that Clematis chinensis may offer a valuable mean of therapy for brain inflammatory diseases.
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KEYWORD
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Clematis chinensis, Lipopolysaccharide, Cyclooxygenase-2, Inducible nitric oxide synthase, Prostaglandin E2, Nitric oxide
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