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KMID : 1200820100100040288
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Oriental Pharmacy and Experimental Medicine
2010 Volume.10 No. 4 p.288 ~ p.293
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Lindera erythrocarpa Makino extract reduces obesity induced by high-fat diet in rats
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Ahn Mee-Jung
Yang Won-Jun
Kang So-Hi
Kang Min-Chul
Ko Ryeo-Kyeong
Kim Gi-Ok
Shin Tae-Kyun
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Abstract
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Lindera erythrocarpa Makino (LE) is widely distributed on Jeju Island, where it has been used for various traditional therapies. Effects of a crude extract of LE were examined in rats with obesity induced by a high-fat diet (HFD). Anti-obesity effects were followed in rats receiving orally administered vehicle, 100mg/kg extract, or 250 mg/kg LE extract, for 56 days. LE extract (250 mg/kg) suppressed increases in body weight and epididymal fat, with amelioration of fatty changes in the liver. Additionally, serum levels of alanine aminotransferase, aspartate aminotransferase, and total cholesterol were significantly decreased compared with those of vehicle-treated groups (p < 0.05). These results suggest that oral administration of LE extract reduced rat obesity induced by HFD, possibly through the reduction of fat accumulation.
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KEYWORD
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Lindera erythrocarpa Makino, Obesity, Rat, Cholesterol
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