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KMID : 1200820100100040310
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Oriental Pharmacy and Experimental Medicine
2010 Volume.10 No. 4 p.310 ~ p.318
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Anti-inflammatory and radical scavenging properties of Verbena officinalis
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Shim Hwan-Ki
Kim Seong-Yeol
Kim Bo-Rim
Cho Jae-Park
Park Yae-Jeong
Ji Won-Geun
Cha Dong-Seok
Jeon Hoon
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Abstract
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Verbena officinalis (Verbenaceae) has been used as herbal medicine or health supplement in both Western and Eastern countries for centuries. In the present study, we examined the anti-inflammatory and antioxidant activities of the methylene chloride fraction of V. officinalis (VMC). To elucidate the anti-inflammatory properties of VMC, we investigated the inhibition effects of nitric oxide production in interferon-gamma (IFN-) and lipopolysaccharide-stimulated mouse peritoneal macrophages. VMC suppressed nitric oxide production, inducible nitric oxide synthase and cyclooxygenase-2 expression dose-dependently without notable cytotoxicity. In various radical scavenging assays, VMC exhibited strong scavenging effect on DPPH radical, superoxide radical, nitric oxide radical and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radical. VMC also showed potent reducing power. These findings strongly suggest that VMC may be beneficial in oxidative stress-mediated inflammatory disorders.
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KEYWORD
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Verbena officinalis, Antioxidant, Anti-inflammatory
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