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KMID : 1200820110110020113
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Oriental Pharmacy and Experimental Medicine
2011 Volume.11 No. 2 p.113 ~ p.118
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Inhibitory effect of Mori Cortex Radicis, Farfarae Flos and Asteris Radix extracts on release of inflammatory mediators in LPS-induced HMC-1 cells
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Kim Ki-Suk
Kim Shin-Hyung
Jang Hyeung-Jin
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Abstract
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Mori Cortex Radicis, Farfarae Flos, Asteris Radix had been prescribed to treat asthmatic symptoms and help to eliminate sputum in oriental pharmacology, but the anti-inflammatory mechanism of the herbs are not sufficiently defined. Here, we investigated the anti-inflammatory mechanism of the herb 80% ethanol extracts on LPS-induced HMC-1 cells. To determine inhibitory effect of the herb extracts on chronic inflammation, expression of COX-2 and production of pro-inflammatory cytokines IL-6 and TNF-α were measured. COX-2 expression was downregulated dose-dependently and release of IL-6 and TNF-α were inhibited by effect of each herb extracts. This study provides information about the cellular mechanism of anti-inflammatory effect of these three herbs extracts which might be helpful to study anti-inflammatory agents.
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KEYWORD
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Mori Cortex Radicis, Farfarae Flos, Asteris Radix, COX-2, TNF-alpha, IL-6
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