KMID : 1200820110110030143
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Oriental Pharmacy and Experimental Medicine 2011 Volume.11 No. 3 p.143 ~ p.146
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Analgesic and anti-inflammatory activities of Alocasia indica (Roxb.) Schott
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Rahman Atiqur
Solaiman Haque Ekramul Das A. K.
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Abstract
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The ethanol extract of the dried rhizome of Alocasia indica (Roxb.) Schott. (Family - Araceae) was investigated for its possible analgesic and anti-inflammatory activities in animal models. The extract showed significant (P?0.001) writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 300 and 600 mg/kg of body weight comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight. Moreover, when given orally to rats at dose of 300 and 600 mg/kg of body weight, the extract showed a significant (P?0.001) anti-inflammatory activity against carrageenin induced paw edema in rats which was comparable to the standard drug aspirin at the dose of 150 mg/kg of body weight. The overall results tend to suggest the analgesic and anti-inflammatory activities of the crude ethanolic extract of dried rhizome of Alocasia indica (Roxb.) Schott. The obtained results provide a support for the use of this plant in traditional medicine and its further investigation.
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KEYWORD
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Analgesic activity, Anti-inflammatory activity, Rhizome, Alocasia indica (Roxb.) Schott
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