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KMID : 1200820110110030153
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Oriental Pharmacy and Experimental Medicine
2011 Volume.11 No. 3 p.153 ~ p.160
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Effect of ammonium glycyrrhizinate on haloperidol- and reserpine- induced neurobehavioral alterations in experimental paradigms
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Otari Kishor Vasant
Shete Rajkumar Virbhadrappa
Bhutada Rupesh Nandkumar
Upasani Chandrashekhar Devidas
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Abstract
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The present work was aimed to assess the effect of ammonium glycyrrhizinate, AG (50, 100, and 150 mg/kg, i.p.) on haloperidol induced catalepsy in mice; reserpine induced orofacial dyskinesia in rats; and reserpine antagonism in mice. Additionally the effect of AG on lipid peroxidation (LP) in cataleptic mice brain and monoamine oxidase-B (MAO-B) levels in normal mice brain was assessed. Administration of AG 100 and 150 mg/kg showed significant reduction in the duration of cataleptic behavior at 60 to 180 min and dose dependent decrease in LP induced by haloperidol. AG showed significant decrease in frequency of vacuous chewing movements at 150 mg/kg and frequency of tongue protrusion at 100 and 150 mg/kg in reserpine induced orofacial dyskinesia test. AG showed significant increase in frequency of horizontal movement and rearing behavior at 150 mg/kg and increase in grooming behavior at 100 and 150 mg/kg in reserpine antagonism test. AG showed dose dependent inhibition of MAO-B in the normal mice brain. These results suggested that AG prevented the haloperidol- and reserpine- induced neurobehavioral alterations possibly by acting as free radical scavenger or inhibiting MAO-B thereby increasing dopaminergic transmition consequently decreasing dopamine metabolites and ultimately preventing the generation of free radicals.
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KEYWORD
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Ammonium glycyrrhizinate, Parkinson’s disease , Haloperidol, Catalepsy, Reserpine, Orofacial dyskinesia, Monoamine oxidase-B, Antioxidant
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