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KMID : 1200820110110030191
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Oriental Pharmacy and Experimental Medicine
2011 Volume.11 No. 3 p.191 ~ p.198
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Antidiabetic and antioxidant effect of methanol extract of edible plant Talinum portulacifolium (Forssk) in Streptozotocin induced diabetic rats
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Thalapaneni Nageswara Rao
Sabapathi Mohana Lakshmi
Ansari Faraz Raza
Mandal Subhash C.
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Abstract
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The aim of this study is to evaluate antidiabetic and antioxidant effects of methanol extract of Talinum portulacifolium (FORSSK) leaves (Portulacaceae) (METP) in streptozotocin induced diabetic rats. The acute and sub acute antihyperglycemic effect of two different doses (200 and 400 mg/kg,) of METP were investigated. Blood glucose level, serum insulin level, lipid profiles and biomarker enzymes were evaluated in normal and diabetic rats. Liver glycogen content, kidney and liver antioxidant enzymes were evaluated. Supplementation of METP by oral gavage significantly reduces the fasting blood glucose level. This supplementation significantly increases the glycogen level in the liver (32.33?±?1.453 mg/gm) as compare to diabetic control group (5.66?±?0.881 mg/gm) (p?
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KEYWORD
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Antidiabetic activity, Antioxidant activity, Histopathology, Streptozotocin, T. portulacifolium
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