|
KMID : 1200820110110030199
|
|
Oriental Pharmacy and Experimental Medicine
2011 Volume.11 No. 3 p.199 ~ p.206
|
|
|
The beneficial effects of Achyranthus bidentata Blume on scopolamine-induced memory impairment in mice
|
|
Oh Sa-Rang
Ahn Eun-Mi
Jung Ji-Wook
|
|
|
Abstract
|
|
|
|
Achyranthus bidentata Blume has traditionally been used to treat a variety of diseases including cough, fever, and asthma. However, the anti-amnesic effects of A. bidentata and its molecular mechanisms have yet to be clearly elucidated. In this study, we attempted to evaluate the effects of A. bidentata on scopolamine-induced memory impairments in mice. The regulatory effect of A. bidentata on memory impairment was investigated using passive avoidance, Y-maze and the Morris water maze tasks. Acetylcholinesterase inhibition assay was performed to investigate the cholinergic antagonistic effect of A. bidentata in hippocampus. The result of this study demonstrated that A. bidentata significantly restored memory impairments induced by scopolamine. Increase of Acetylcholinesterase activity caused by scopolamine was significantly attenuated by A. bidentata. In addition, A. bidentata recovered the reduction of cAMP-responsive element-binding protein activation induced by scopolamine in the hippocampus. Taken together, the results provide experimental evidence that A. bidentata might be a useful agent against a deficit of learning and memory caused by Alzheimer’s disease and aging.
|
|
|
KEYWORD
|
|
|
Achyranthus bidentata Blume, Scopolamine, Memory, Acetylcholinesterase, cAMP-responsive element-binding protein (CREB)
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|