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KMID : 1200820110110040229
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Oriental Pharmacy and Experimental Medicine
2011 Volume.11 No. 4 p.229 ~ p.234
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Hepatotoxic and invivo antioxidant potential of Pandanus odoratissimus against carbon tetrachloride induced liver injury in rats
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Londonkar Ramesh L.
Kamble Abhaykumar
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Abstract
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The present study was carried out to evaluate the antioxidant effect of methanol extract of Pandanus odoratissimus lim (MEPO) leaf in wistar albino rats. The animals were grouped differently and administered with Carbon tetrachloride (CCl4) (1.5/kg?1 CCl4 1 ml kg?1 in liquid paraffin 3 doses (i.p) at 72 h interval). The extracts at the doses of 50 and 100 mgkg?1 and Liv 52 25 mg kg?1 were administered to the CCl4 treated rats. The effect of extract and Liv 52 on serum transaminase (GOT, GPT), alkaline phosphatease (ALP), bilirubin and total protein were measured in the rat induced by CCl4. The effect of extract on lipid peroxidation (LPO), Superoxide Dismutase (SOD), Catalase (CAT), Glutathione (GSH) and Vitamin E were estimated. The extract and Liv 52 produced significant (P?
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KEYWORD
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Antioxidant, Hepatoprotective effects, Carbon tetrachloride, Rats
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