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KMID : 1200820110110040251
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Oriental Pharmacy and Experimental Medicine
2011 Volume.11 No. 4 p.251 ~ p.255
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Neuropharmacological assessment of Curcuma caesia rhizome in experimental animal models
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Karmakar Indrajit
Saha Pathik
Sarkar Nilanjan
Bhattacharya Sanjib
Haldar Pallab K.
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Abstract
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Curcuma caesia Roxb. (Zingiberaceae), called black turmeric in English, is a perennial herb found throughout the Himalayan region, North-East and Central India. The plant has been traditionally used in India for several medicinal purposes. The present study was carried out to evaluate the methanol extract of C. caesia rhizome (MECC) for some neuropharmacological activities in experimental animal models. MECC (at 50 and 100 mg/kg body weight) was evaluated for analgesic activity by acetic acid-induced writhing and tail flick tests. Locomotor activity was measured by means of an actophotometer. Anticonvulsant property was assessed against pentylenetetrazol-induced convulsion in mice and muscle relaxant effect was evaluated by using rota-rod apparatus. The results of the present study revealed remarkable analgesic, locomotor depressant, anticonvulsant and muscle relaxant effects of C. caesia rhizome, demonstrating depressant action on the central nervous system. The outcome of present study can validate certain traditional uses of C. caesia rhizome in India.
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KEYWORD
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Analgesic, CNS depressant, Convulsion, Locomotor, Muscle relaxant
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